Chang Media

For more than 30 years, chromosomes from fetal cells cultured in vitro have been used to diagnose prenatal genetic abnormalities. Both the methods and the nutrient media used for the culture of these cells have evolved significantly over this period. A significant advance was reported by Chang et al. in 1982, which subsequently led to the development of Chang Medium®, specifically designed for the culture of amniotic fluid cells (AFC). Since the introduction of this medium, Irvine Scientific have developed additional formulas which are intended to address cultures that are maintained in open or closed systems in addition to the in situ culture technique. The Chang range of media provide optimal growth conditions for amniotic fluid cell samples and CVS cultures to ensure rapid harvest times and high levels of mitotic cells. Technical data sheets and evaluation study reports of all formulations are available upon request.